Which of the following is one of the key factors that differentiate major depression from periods of sadness that everyone experiences?

1
People who experience major depression are sad for longer than two weeks without an obvious cause.
2
Individuals diagnosed with major depression experience sadness along with episodes of heightened emotions and mania.
3
All mood disorders, like major depression involve tolerance and withdrawal of controlled substances.
4
Normal periods of sadness are much less intense than the sadness associated with major depression.

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