Comprehension Passage

Read the given passage carefully and answer the following questions.

What future lies ahead for humans in space? Last year, the 50th anniversary of the first moon landing found a host of private and governmental projects that aim to send astronauts far beyond the near-Earth orbits that have limited human space exploration since 1972. China, which landed the first spacecraft on the lunar far side in 2019, has plans to place astronauts on the moon. India, which crashed a lander on the moon in 2019, dreams of doing likewise. Russia, which doesn’t seem to have much of an ongoing astronaut program, still provides the rockets and launch facilities that provide astronauts with access to the International Space Station. The Trump administration proposes to create a lunar base as a key step in sending astronauts to Mars. Elon Musk and Jeff Bezos have spent large sums on future human space missions. Indeed, Musk has already created a thriving rocket business, which NASA uses to resupply the Space Station, 250 miles above Earth’s surface.
But the past five decades have taught a clear lesson about how best to explore the cosmos. People venturing into space are fragile: They require a continuous supply of oxygen, water, food, and shelter. In contrast, automated spacecraft requires only a power supply. They cost far less than humans do, and we know how to improve them every year. And if they fail, we lose only dollars and scientific results.
None of our discussion and suggestions looks beyond the next few decades, a sufficiently long stretch of time to beware of the accuracy of our predictive abilities. If human civilization successfully overcomes its current problems and achieves long-term stability, we shall certainly send people to the other worlds in our solar system. If we create human colonies in space, their inhabitants might undergo evolutionary changes that make them more fit for space travel. If, as is likely to happen soon, we can manipulate the human genome as we like, we could manufacture a new set of beings designed for space travel.
None of these “ifs” tells us much about what we should do within the next few years. Nor do they rule out machines as superior to whatever humans we may invent. Meanwhile, we would do well to ponder the current advantages that our automated explorers of realms close to Earth maintain over their human counterparts. 

Which of the following best expresses the similar meaning of the word “manipulate” as used in the passage?

1
Culprit
2
Culpable
3
Cultural
4
Influence

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