Which of the following is a key difference between prokaryotic and eukaryotic cells?

1
Prokaryotic cells have a nucleus, eukaryotic cells do not
2
Prokaryotic cells lack a cell wall, while eukaryotic cells have one 
3
Prokaryotic cells lack membrane-bound organelles, whereas eukaryotic cells have them 
4
Eukaryotic cells are smaller in size compared to prokaryotic cells 

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