In the context of virus attenuation, which of the following statements best describes the term "Codon De-optimisation"?

1
A method of enhancing the virulence of a virus by increasing the frequency of under-represented codon pairs.
2
A genetic editing technique that changes the amino acid sequences to make a virus more contagious.
3
A strategy to reduce the frequency of under-represented codon pairs without altering amino acid sequences, used to safely attenuate viruses.
4
A process of accelerating the mutation rate of a virus to study its evolutionary patterns.
5
Question Not Attempted

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