Statements related to human Insulin are given below. Which statement(s) is/are correct about genetically engineered Insulin?

(a) Pro-hormone insulin does not contain an extra stretch of C-peptide.

(b) A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted, and combined by creating a disulfide bond between them.

(c) Insulin used for treating Diabetes was extracted from cattle and Pigs.

(d) Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone.

(e) Some patients develop allergic reactions to foreign insulin.

Choose the most appropriate answer from the options given below: