What is the principle of “preorganization” in supramolecular chemistry?
1
The principle that the more disordered the host-guest complex, the more stable it is
2
The principle that the host must be structurally optimized for binding before the complexation occurs
3
The principle that the more polar the solvent, the better the complex will form
4
The principle that only hydrophobic interactions drive the stability of supramolecular complexes