Which one of the following statements is not correct with regard to genetically modified organisms (GMO)?

1
They are living organisms whose genetic material has been artificially manipulated in a laboratory.
2
Most GMOs have been engineered to withstand the direct application of herbicide and/or to produce an insecticide.
3
This creates combinations of plant, animal, bacteria, and virus genes that do not occur in nature or through traditional crossbreeding methods.
4
The GMO production imposes no risks to the disruption of ecosystem and biodiversity.

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