Indicate the INCORRECT statement from the following: 

1
Allosteric enzymes function through reversible noncovalent binding of allosteric modulators or effectors.
2
Monoclonal antibodies that catalyze hydrolysis of esters or carbonates can be produced.
3
Enzymes are not inhibited irreversibly by heavy metals such as Hg2+, Ag+.
4
Acid phosphatases hydrolyze biological phosphate esters at ~ pH 5.0. 
5
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