A change of Gαi that blocks the release of bound GDP is catalysed by the toxin generated by Bordetella pertussis, a bacterium that frequently infects respiratory tract cells and causes whooping cough. Gαi as a result is

1
locked in an inactive state, decreasing adenylyl cyclase inhibition
2
 locked in the active state, decreasing adenylyl cyclase inhibition
3
locked in the inactive state, increasing adenylyl cyclase inhibition
4
locked in the active state, increasing adenylyl cyclase inhibition
5
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