In order to study the transcription factor TFIIH, it was cloned from a large number of human subjects. Surprisingly, the subjects having mutation in TFIIH, also showed defects in their DNA repair system. Given below are the explanations:
P. DNA damage is always associated with transcription inhibition.
Q. TFIIH has no role in DNA repair.
R. In mammalian system, TFIIH plays an active role in transcription coupled DNA repair process.
S. Because of mutation in TFIIH, transcription initiation is inhibited and incompletely synthesized mRNAs remain attached to the template DNA leading to DNA damage.
Choose the correct answer?

1
P and Q
2
R only
3
Q and S
4
S only
5
Question Not Attempted

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