During heat shock, mammalian cells shut down global protein synthesis while inducing heat shock proteins. The possible molecular  regulations that could explain the phenomenon are:

 A. mRNA  of all proteins except those of HSPs  undergo degradation during heat shock 

B. Cap-dependent translation of most mRNAs is affected during heat shock due to denaturation of the cap-binding protein eIF-4e.

C. Translation initiation of HSP mRNAs takes place through their internal ribosome entry size IRES

D. HSP mRNAs are abundant during heat shock, and thus they compete with other mRNAs for ribosome binding and translation.

Which of the following sets is correct:

 

1
A and B
2
B and C
3
A and C
4
A and D
5
Question Not Attempted

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