In the hypothalamic-pituitary-adrenal (HPA) axis, what role does cortisol play in the feedback mechanism?

1
Cortisol inhibits the release of corticotropin-releasing hormone (CRH) from the hypothalamus and adrenocorticotropic hormone (ACTH) from the pituitary gland.
2
Cortisol stimulates the hypothalamus to release more CRH, enhancing its own production.
3
Cortisol directly stimulates the anterior pituitary to secrete ACTH, bypassing the hypothalamus.
4
Cortisol acts exclusively on the adrenal cortex, with no feedback effects on the hypothalamus or pituitary.
5
Question Not Attempted

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