Teaching Haryana (HPSC) Assistant Professor Mock Test 2025 Life Sciences Cell Communication and Cell Signaling Cancer
Many cancers carry mutant p53 genes, while some cancers have normal p53 genes. p53 activates p21 (Waf 1) which inhibits G1/S-Cdks and phosphorylation of the retinoblastoma protein (Rb). Cancers with normal p53 genes could
1
express non-phosphorylatable form of Rb.
2
express high levels of p53-deubiquitinases.
3
express inactive forms of G1/S-cdks.
4
express inactive forms of G1/S cyclins.
5
Question Not Attempted