Certain statment are made regarding specification of germ layers in Amphibia. Select the incorrect statement.

1
The “bottom-up” specification of the frog embryo resides in a set of mRNAs that are tethered to the vegetal cortex.
2
VegT is critical in generating both endodermal and mesodermal lineages.
3
VegT encodes Nodal paracrine factors that instruct the cell layers above them to become ectoderm
4
If either Nodal or Vg1 signaling is blocked, there is little or no mesoderm induction
5
Question Not Attempted

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