The following statements summarize metamorphosis and regeneration.

A. Many changes during amphibian metamorphosis are regionally specific. Although the tail epidermis never dies, the head epidermis does.

B. In neoteny, the juvenile form is slowed down, while the gonads and germ cells mature at their normal rate.

C. In epimorphosis, tissues never dedifferentiate into a blastema, divide, or re-differentiate into the new structure.

D. In the regenerating salamander limb, the epidermis forms an apical ectodermal cap. The cells beneath it dedifferentiates to form a blastema.

E. In hydras, there appear to be head activation gradients, head inhibition gradients, foot activation gradients, and foot inhibition gradients.

Which one of the following options has the correct combination of statements that will lead to normal developmental outcome in organisms?