The following statements have been made regarding cell specification in an early embryo:

A. The entire embryo rarely interacts with its environment, and its developmental trajectory cannot be guided by its immediate "ecosystem".

B. When cells are removed, changes in cellular biochemistry and function are never preceded by a process involving the commitment of the cell to a certain fate.

C. The fate of a cell or a tissue in the intact embryo is said to be specified when it is not capable of differentiating autonomously on being placed in a neutral environment, such as a petri dish or test tube.

D. If cells are removed, the interactions of the remaining cells compensate the fate of the removed cells, because the fate of a cell depends upon the conditions in which the cell finds itself.

With regard to the experiment shown below, where removal of cells from an early blastula leads to normal development of the larval form, which one of the above combination of statements apply to the development of the organism?