Which one of the following statements is true about human chromosomes?
1
The chromosomes that have highest gene density generally localize towards the centre of the nucleus.
2
The chromosomes that have highest gene density generally localize near the nuclear periphery to facilitate rapid transport of the nascent transcripts.
3
The centromeres of different chromosomes tend to cluster together at the centre of the nucleus.
4
Chromosomal positioning in the nucleus is absolutely random.