Which one of the following statements about cancers is INCORRECT?

1
The c‐myc gene is translocated to one of the immunoglobulin loci in a majority of Burkitt's lymphomas.
2
Viral integration into the cellular genome may convert a proto‐oncogene into an oncogene.
3
The functions of p53 and Rb are augmented by E6 and E7 proteins of human papillomavirus.
4
Many cases of metastatic breast cancer display increased expression of human epidermal‐growth‐factor–like receptor 2(HER2). 

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