Consider the following statements:

A. Coenzyme B12 is an organometallic compound

B. Pyridoxal phosphate is a co‐factor used by many amino‐ transferases.

C. The affinity of biotin for avidin is one of the highest binding affinities known in biochemistry

D. Enzymes catalyse biochemical reactions by lowering the energy of the transition state

Which one of the following options represents all correct statements?