Teaching MPPSC Assistant Professor Mock Test Series 2025 Life Sciences Cell Communication and Cell Signaling
In the context of receptor tyrosine kinase (RTK) signaling pathways, which of the following statements accurately describes the role of IP3 and DAG produced as a result of the activation of phospholipase Cγ (PLCγ)?
1
IP3 diffuses through the cytoplasm and binds to IP3 receptors on the mitochondrial membrane, directly stimulating the production of ATP, while DAG remains in the membrane, deactivating nearby RTKs
2
DAG activates protein kinase A (PKA), leading to the enhancement of cellular metabolism, whereas IP3 binds to its receptor on the nuclear membrane, modifying gene transcription.
3
IP3 binds to its receptors on the endoplasmic reticulum (ER) membrane, causing the release of calcium ions into the cytosol, while DAG activates protein kinase C (PKC), which then phosphorylates various target proteins.
4
Both IP3 and DAG are transported out of the cell where they function as secondary messengers to neighboring cells, thereby propagating the RTK signal externally.