Teaching MPPSC Assistant Professor Mock Test Series 2025 Life Sciences Cell Communication and Cell Signaling Cancer
The tumor suppressor protein p53 plays a critical role in regulating the cell cycle and preventing cancerous growth. Its functionality is largely attributed to its structure, which includes specific domains crucial for its activity. Which of the following statements accurately describes the roles of the N-terminal, DNA-binding domain (DBD), and C-terminal regions of p53?
1
The N-terminal region contains the DNA-binding domain (DBD), responsible for directly interacting with target gene promoters, while the C-terminal region is involved in oligomerization, essential for p53's transcriptional activity.
2
The DNA-binding domain (DBD) is located in the C-terminal region and is responsible for p53's interaction with DNA, while the N-terminal region contains a transactivation domain critical for the recruitment of transcriptional coactivators.
3
The DNA-binding domain (DBD) is centrally located and is responsible for the specific recognition and binding to DNA sequences of target genes. The N-terminal region contains a transactivation domain crucial for interaction with other proteins in the transcription machinery, and the C-terminal region is involved in regulating p53's DNA-binding affinity and specificity through post-translational modifications
4
The N-terminal region is primarily responsible for the degradation of p53 via the proteasome pathway. At the same time, the DNA-binding domain (DBD) and C-terminal region are both located in the central part of the protein, mediating the recruitment of histone acetyltransferases.