Cortisol is synthesized in the adrenal cortex primarily in the zona fasciculata. This process is regulated by ACTH (adrenocorticotropic hormone). A key enzyme essential for the conversion of 17α-hydroxyprogesterone to 11-deoxycortisol in cortisol synthesis is:

1
17 α-hydroxylase
2
21-hydroxylase
3
11 β-hydroxylase
4
18-hydroxylase

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