Which one of the following statements is true with respect to optical activity?
1
A relationship exists between the (R) and (S) configurations of enantiomers and the direction [(+) or (-)] in which they rotate plane- polarized light.
2
Equimolar mixture of D and L isomers of the same compound will be optically active
3
Mesocompounds that are optically inactive may contain stereogenic centers or chiral centers
4
Optical activity is independent of temperature.