The discovery that a gene can be divided into hundreds of components, each of which is capable of mutation, is attributed to Seymour Benzer. This was concluded using:

1
Lysis mutants of bacteriophage T4 
2
White eye Mutants of Drosophila melanogaster
3
Biochemical mutants of Neurospora crassa.
4
Auxotrophic mutants of Escherichia coli.

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