In the sentence, certain words are in bold and numbered from A to E, which are the possible pairs to be interchanged. Choose the pair(s) of words which need to be interchanged to make the sentence grammatically correct and meaningful. 

(A) Speculatively, it suggests that (B) undernourishment social isolation might be something like long-term (C) chronic, producing steady, (D) aversive need that (E) wears away at our well-being.