Cancer is a major cause of death worldwide, and rising drug and alcohol abuse, especially among youth, only exacerbates health concerns. Drugs like opioids, cannabinoids, and coca alkaloids, derived from plants and fungi, pose significant risks. Opioids bind to specific receptors in the central nervous system and gastrointestinal tract, leading to harmful effects. The body's ability to defend against diseases, including cancer, depends on its immune system, which is categorized as innate or acquired immunity. Proper education and guidance are crucial to help youth avoid these dangerous substances and maintain healthy lifestyles, supporting overall immunity and reducing cancer risk.