Given below are two statements : One is labelled as Assertion (A) and the other is labelled as Reason (R).

Assertion (A): Specific amino acids may be replaced individually by site directed mutagenesis. This powerful approach to studying protein structure and function changes the amino acid sequence of a protein by altering the DNA sequence of cloned gene. 

Reasons (R): When suitably located restriction site A are not present in the sequence to be altered, an approach called oligonucleotide-directed mutagenesis can create a specific DNA sequence change.

In the light of the above statements, choose the most appropriate answer from the options given below:

1
Both (A) and (R) are true and (R) is the correct explanation of (A) 
2
Both (A) and (R) are true but (R) is NOT the correct explanation of (A)
3
(A) is true but (R) is false
4
(A) is false but (R) is true

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