Why is the presence of proline destablizes a-helix?
A. Proline residue introduces a destablizing kink in the a-helix
B. In proline, the nitrogen atom is a part of a rigid ring, and rotation about N-C bond is not possible
C. The nitrogen atom of a proline residue in a peptide linkage has no subsituent hydrogen to participate in hydrogen bonds with other residues
D. Proline residue works as a helix linker
Choose the correct answer from the options given below:
1
(A), (B) and (D) only
2
(A), (B) and (C) only
3
(A), (B). (C) and (D)
4
(B). (C) and (D) only