Below are given a set of statements for the glucocorticoid hormones:

A. They bind to cell surface receptors and influence stress adaptation

B. They bind to intracellular receptors and influence stress adaptation

C. They inhibit ACTH secretion from anterior pituitary

D. Prolonged treatment with glucocorticoids leads to atrophic and unresponsive adrenals

E. Their secretion does not show circadian variations

Which one of the following combination of the statements is correct?

1
A, C and E
2
B, C and D
3
C, D and E
4
A, D and E

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