PG entrance exam CUET PG 2025 Mock Test Life Sciences Fundamental Processes DNA replication, repair and recombination
The basic difference between direct repair and base excision repair is
1
Direct repair restores original structure of altered nucleotide without replacement, while in base excision repair the section of DNA containing the distortion is removed, the correct base is added and resealed.
2
In direct repair, homologous recombination repairs the broken region while base excision repair restores original structure of altered nucleotide by modification.
3
Direct repair restores original structure by non‐homologous end joining without using homologous template while in base excision repair the section of DNA containing the distortion is repaired by using homologous recombination.
4
In direct repair, an exonuclease, a DNA polymerase and a ligase are used, while in base excision repair a translesion polymerase that bypasses the bulky lesions is used by the cell.