Which of the following are mechanisms by which bacterial plasmids confer antibiotic resistance?

A. Degradation of the antibiotic via specific enzymes.
B. Modification of the antibiotic target site to reduce binding affinity.
C. Active efflux of the antibiotic from the bacterial cell.
D. Uptake of the antibiotic through pore-forming proteins.

Which combination best describes the mechanisms by which bacterial plasmids confer resistance?