Following statements were made about chromatin remodeling in eukaryotes:

A. Chromatin remodeling completely alters and/or slides the nucleosome, but cannot displace it.

B. Chromatin remodeling is an energy driven, developmentally regulated active process.

C. Histone acetylation is a reversible process, in which each direction of the reaction is catalyzed by different enzymes.

D. In general, acetylation of core histones reduces their affinity for DNA and destabilizes the chromatin structure, causing transcriptional repression.

E. Phosphorylation of Ser1 of histone H2A has been associated with transcription repression.

Which one of the following represents the combination of correct statements?