Directions: Rearrange the following sentences in the proper sequence to form a meaningful paragraph and then answer the questions given below.

A. Because of the lack of direct head-to-head comparison in clinical trials, it is unknown whether a shorter duration of treatment may be just as effective than the accepted practice of treatment for one year.

B. The optimal duration of add-on trastuzumab treatment after surgery for early breast cancer is unknown.

C. However, a small Finnish trial also showed similar improvement with nine weeks of treatment over no therapy.

D. The debate about treatment duration has become a relevant issue for many public health policymakers because administering trastuzumab for a year is very expensive.

E. One year of treatment is generally accepted based on clinical trial evidence that demonstrates the superiority of one-year treatment over none.