Direction: In the following passage some words have been deleted. Fill in the blanks with the help of the alternatives given. Select the most appropriate option for each blank.
Quinine was the first chemical compound that was successful against any infectious disease. When it was brought to Europe in the 17th century, quinine was hailed as a miracle-drug against malaria. Until then, malaria was widespread (1)______ Europe and the tropical regions. The disease was highly feared because it had no known cure at the time. The illness usually began with flu-like symptoms and progressed to nausea and high-fever, sometimes (2)______ to death. With no effective remedy at hand, doctors could only (3)______ the symptoms. Back then, people did not know that it was caused by a parasite (4)______ through mosquito bites. But they found a link between the disease and stagnant water in marshes and so, called it "marsh-fever". The indigenous peoples of Peru used the bark of the cinchona tree to control malaria. The Jesuits studied the (5)______ of the medicine and introduced the treatment to Europe during the 1640s, where it was rapidly accepted. It was not until 1820 that the active ingredient, quinine, was extracted from the bark, isolated and named by French chemists.