Identify the option that rearranges the given jumbled words and correctly fills in the blank.

Schizophrenia, a chronic mental disorder, ________ of the brain.

the / produced / premature / deterioration / by / is

1
is produced by the premature deterioration 
2
is produced premature by the deterioration
3
the deterioration produced premature by is
4
premature deterioration produced is by the

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