In the sentence, certain words are in bold and numbered from A to E, which are the possible pairs to be interchanged. Choose the pair(s) of words which need to be interchanged to make the sentence grammatically correct and meaningful. 

Towards the end of the period of isolation, there is a (A) renewed (B) vigour and a sense of relief but I have also learnt to exercise particular (C) caution during this time since sailboats are (D) destination for not arriving at their (E) notorious on time.