Study the following information carefully and answer the given questions:

If ‘P 2 Q’ means ‘P is the sister of Q’

If ‘P 3 Q’ means ‘P is the brother of Q’

If ‘P 4 Q’ means ‘P is the mother of Q’

If ‘P 5 Q’ means ‘P is the father of Q’

If ‘F 2 R 5 I 3 E 4 N 2 D’ is given, then how is F related to E?