Which of the following works helped to establish the relationship of a gene to control synthesis of one enzyme?

1
The work of George Beadle and Edward Tatum during 1930s on the mould Neurospora crassa
2
The work of Bateson and Edward Tatum during 1930s on the mould Neurospora crassa 
3
The work of Morgan and Edward Tatum during 1930s on the mould Neurospora crassa 
4
The work of Johansen and Edward Tatum during 1930s on the mould Neurospora crassa 

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