The protein hemoglobin exhibits a sigmoidal oxygen binding curve due to

1
High oxygen affinity of individual subunits
2
Low pCOIn tissuespCO2" id="MathJax-Element-10-Frame" role="presentation" style="position: relative;" tabindex="0">pCO2Unknown node type: span" id="MathJax-Element-1-Frame" role="presentation" style="position: relative;" tabindex="0">pCO2Unknown node type: span
3
Cooperative binding of oxygen molecules
4
A high pH in red blood cells

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