Which of the following is the main difference between cryptands and crown ethers in terms of their binding

1
Cryptands bind guests via oxygen atoms, while crown ethers bind via nitrogen atoms.
2
Cryptands are more selective and stronger in their binding due to their three-dimensional structure.
3
Cryptands bind exclusively to neutral molecules, while crown ethers bind only to cations.
4
Cryptands form complexes with only alkali metals, whereas crown ethers can bind both alkali and alkaline earth metals.

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