Which of the following is NOT TRUE with respect to control of respiration?

1
Peripheral chemoreceptors respond to changes in O2 and CO2 concentration in the blood. 
2
Respiration responds to smaller changes, in the blood concentration of O2 than CO2.
3
Chemoreceptors in the CNS respond to changes in CO2 concentration in the blood.
4
Central chemoreceptors are sensitive to changes in pH of the cerebrospinal fluid.

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