How do humans acclimatise at high altitudes where atmospheric pressure is low for normal breathing?

1
By decreasing red blood cell production, decreasing the binding affinity of haemoglobin and by increasing breathing rate 
2
By increasing red blood cell production, decreasing the binding affinity of haemoglobin and by increasing breathing rate 
3
By hibernating
4
By increasing white blood cell production, decreasing the binding affinity of haemoglobin and by increasing breathing rate
5
Not Attempted

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