Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

1
Both are due to a qualitative defect in globin chain synthesis.
2
Both are due to a quantitative defect in the globin chain synthesis.
3
Thalassemia is due to less synthesis of globin molecules.
4
Sickle cell anemia is due to a quantitative problem of globin molecules.

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