Inversions are considered as cross-over suppressors because

1
Homozygous inversions are lethal and thus they do not appear in next generation
2
Inversion heterozygotes, i.e., one copy having normal chromosome and its homologue having inversion, does not allow crossing over to occur as they cannot pair at all
3
Due to inversion present, four chromosomes take part in the pairing and crossing over events and make the structure difficult for separation and gamete formation
4
The pairing and crossing overs do occur in inversion heterozygotes but the gametes having cross over products are lethal
5
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