Teaching Haryana (HPSC) Assistant Professor Mock Test 2025 Life Sciences Fundamental Processes Protein synthesis and processing
The wobble hypothesis explains how mRNA codons can be efficiently translated despite a limited number of tRNA molecules. Based on this hypothesis, which of the following statements is most accurate regarding the pairing between the 3rd base of a codon and the 1st base of the corresponding anticodon in tRNA?
1
Strict Watson-Crick base pairing rules apply, requiring exact matching between the 3rd base of the codon and the 1st base of the anticodon.
2
The 3rd base of the mRNA codon cannot form hydrogen bonds with the 1st base of the tRNA anticodon, thereby allowing for wobble and multiple codon recognition.
3
The 3rd base of the mRNA codon and the 1st base of the tRNA anticodon often engage in non-standard base pairing, allowing a single tRNA to read multiple codons.
4
The wobble hypothesis suggests that only purines can pair with pyrimidines at the wobble position, strictly limiting the versatility of codon-anticodon pairing.
5
Question Not Attempted