During DNA replication in eukaryotes, helicase unwinds the DNA double helix. If a mutation in the gene encoding helicase reduces its processivity by 50%, which of the following processes would most likely be disrupted first in the lagging strand?
1
Primer synthesis by primase
2
Unwinding of the replication fork
3
Ligating Okazaki fragments by DNA ligase
4
Removal of RNA primers by RNase H
5
Question Not Attempted