The following statements have been proposed for a cancer cell.

A. Binding of p53 with MDM2, a ubiquitin E3 ligase; is a precondition for cancer progression.

B. Phosphorylation of a tyrosine residue in the C- terminus of human c-Src is essential for cell invasion and motility.

C. Loss of function of both alleles of a tumor Suppressor gene prevents metastasis.

D. Dimerization of C-myc-Max leads to enhanced cell proliferation.

Which of the combinations of the above statements is correct?

1
 A and B
2
 A and D
3
C and D
4
B and C
5
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