Teaching Haryana (HPSC) Assistant Professor Mock Test 2025 Life Sciences Cell Communication and Cell Signaling Cell signaling
Which of the following best describes the sequence of events during the regulation of GPCR-mediated signaling pathways through receptor internalization?
1
The GPCR is phosphorylated by GRKs, β-arrestin binds to the phosphorylated receptor, β-arrestin recruits the adaptor complex AP-2 and clathrin, leading to receptor internalization through clathrin-mediated endocytosis.
2
The GPCR directly recruits the clathrin protein without any modifications, leading to its internalization and downregulation without participating in any signaling events.
3
β-arrestin phosphorylates the GPCR, which then directly activates adenylate cyclase, leading to an increase in cyclic AMP production and receptor internalization.
4
The AP-2 adaptor complex directly phosphorylates the GPCR, which then binds to β-arrestin, uncoupling the G protein and preventing receptor internalization.
5
Question Not Attempted