The Ran GTPase imposes directionality on transport through nuclear pore complexes (NPCs). Like other GTPases, Ran is a molecular switch that can exist in two conformational states, depending on whether bound to GDP or GTP. Possible reasons for compartmentalization of Ran-GTP accumulation are:
A. Ran-GAP is enriched in the nucleus
B. Ran-GAP is localized in the cytosol
C. Ran-GEF is enriched in the nucleus
D. The nuclear import receptors help in the compartmentalization of Ran-GTP
Which of the options below has all the correct statements about Ran-GTP compartmentalization?
1
A only
2
A and B
3
B and C
4
C and D