The following statements refer to mechanisms that may confer resistance to antibiotics in bacteria.

A. Enzymes that can break down the antibiotic.

B. Efflux systems to pump out the antibiotic.

C. CRISPR-mediated defence against the antibiotic.

D. Antitoxins that can sequester the antibiotic.

E. Cell wall modification.

Which one of the following options represent the combination of all correct statements?